Due to the recent intensified occurrence of allergic diseases, antihistamines have become extremely popular. Based on the available data, we compare pharmacological and clinical properties of cetirizine with other main antihistamines. Cetirizine, belong to the group of antihistamines, is a second generation drug. It competes with free histamine in binding with the H1 receptor. It is a potent, selective, oral histamine H1 receptor antagonist of the second generation. Cetirizine has an advantageous pharmacological profile including high bioavailability, rapid onset of action, high affinity for the H1-receptor, limited volume of distribution, minimal hepatic metabolism, a low potential for drug interactions and a lack of effect on the cardiovascular system, cognition and psychomotor function. Is mainly used in the course of seasonal or chronic allergic rhinitis or chronic, including idiopathic, urticaria. Apart from its antihistaminic effect, cetirizine is characterized by anti-inflammatory influence achieved by inhibiting the synthesis of pro-inflammatory mediators. The application of cetirizine rarely results in undesirable effects and a convenient form of the pharmaceutic makes cetirizine widely recommended by doctors. Pharmacokinetic and pharmacodynamic parameters, as well as the results of conducted and published clinical studies, indicate that drugs containing cetirizine are safe and effective.